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Article

Muramyl dipeptide-induced differential gene expression in NOD2 mutant and wild-type Crohn's disease patient-derived dendritic cells.

Inflammatory bowel diseases - 1 Feb 2008

Zelinkova Zuzana, van Beelen Astrid J, de Kort Floor, Moerland Perry D, Ver Loren van Themaat Emiel, te Velde Anje A, van Deventer Sander J, de Jong Esther C, Hommes Daniel W

Abstract excerpt

BACKGROUND: Mutations in the gene encoding the nucleotide-binding oligomerization domain 2 (NOD2) protein are associated with Crohn's disease (CD), but the mechanism underlying this is not completely understood. To study the mechanism of CD resulting from NOD2 mutations, we analyzed NOD2-dependent whole-genome expression profiles of patient-derived antigen-presenting cells. PATIENTS AND METHODS: Monocyte-derived...

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Identifiers

PMID: 17941075
DOI: 10.1002/ibd.20308

Genes

NOD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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