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Article

Impaired dendritic cell function in Crohn's disease patients with NOD2 3020insC mutation.

Journal of leukocyte biology - 1 Apr 2006

Kramer Matthijs, Netea Mihai G, de Jong Dirk J, Kullberg Bart Jan, Adema Gosse J

Abstract excerpt

The nucleotide oligomerization domain 2 (NOD2) 3020insC (NOD2fs) mutation increases susceptibility to Crohn's disease (CD), but the mechanism remains controversial. Loss-of-function and gain-of-function phenotypes have been described as a result of NOD2fs. Here, we show that dendritic cells (DC) derived from CD patients homozygous for this mutation respond normally to purified Toll-like receptor (TLR) ligands but...

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Source

Identifiers

PMID: 16461743
DOI: 10.1189/jlb.0805484

Genes

NOD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Impaired dendritic cell function in Crohn's disease patients with NOD2 3020insC mutation.PMID 16461743Read ↗

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Normal responses to specific NOD1-activating peptidoglycan agonists in the presence of the NOD2 frameshift and other mutations in Crohn's disease.Semantic proximity Read ↗

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