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Article

Analysis of NOD2-mediated proteome response to muramyl dipeptide in HEK293 cells.

The Journal of biological chemistry - 27 Jan 2006

Weichart Dieter, Gobom Johan, Klopfleisch Sina, Häsler Robert, Gustavsson Niklas, Billmann Susanne, Lehrach Hans, Seegert Dirk, Schreiber Stefan, Rosenstiel Philip

Abstract excerpt

NOD2, a cytosolic receptor for the bacterial proteoglycan fragment muramyl dipeptide (MDP), plays an important role in the recognition of intracellular pathogens. Variants in the bacterial sensor domain of NOD2 are genetically associated with an increased risk for the development of Crohn disease...

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Source

Identifiers

PMID: 16257953
DOI: 10.1074/jbc.M505986200

Genes

NOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16257953-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Analysis of NOD2-mediated proteome response to muramyl dipeptide in HEK293 cells.PMID 16257953Read ↗

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Nod2 Is a General Sensor of Peptidoglycan through Muramyl Dipeptide (MDP) DetectionSemantic proximity Read ↗

Enhancement of Muramyl Dipeptide-Dependent NOD2 Activity by a Self-Derived Peptide.Semantic proximity Read ↗

NOD2/CARD15 mediates induction of the antimicrobial peptide human beta-defensin-2.Semantic proximity Read ↗

Towards an understanding of the role of NOD2/CARD15 in the pathogenesis of Crohn's disease.Semantic proximity Read ↗

Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease.Semantic proximity Read ↗

Identification and biological consequences of the O-GlcNAc modification of the human innate immune receptor, Nod2.Semantic proximity Read ↗

Normal responses to specific NOD1-activating peptidoglycan agonists in the presence of the NOD2 frameshift and other mutations in Crohn's disease.Semantic proximity Read ↗

Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-{kappa}B activation in muramyl dipeptide recognition.Semantic proximity Read ↗

Nod2-Dependent Th2 Polarization of Antigen-Specific ImmunitySemantic proximity Read ↗

NOD2 mutations affect muramyl dipeptide stimulation of human B lymphocytes and interact with other IBD-associated genes.Semantic proximity Read ↗

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