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Article

NOD2 engagement induces proinflammatory cytokine production, but not apoptosis, in leukocytes isolated from patients with Crohn's disease.

European cytokine network - 1 Dec 2008

Bodar Evelien, Netea Mihai G, de Jong Dirk J, Kullberg Bart-Jan, Joosten Leo A B, Van der Meer Jos W M

Abstract excerpt

BACKGROUND: NOD2/CARD15 is a member of the NACHT-LRR (NLR) family of proteins, which recognize the muramyl dipeptide motif from bacterial peptidoglycans. NOD2 has been shown to be involved in the pathogenesis of Crohn's disease. NLR proteins modulate inflammation and apoptosis, and several studies have implicated NOD2 in the induction of cytokines and inflammatory reactions. However, only scarce data are...

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Source

Identifiers

PMID: 19103524
DOI: 10.1684/ecn.2008.0140

Genes

NOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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