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Article

Consequence of functional Nod2 and Tlr4 mutations on gene transcription in Crohn's disease patients.

Journal of molecular medicine (Berlin, Germany) - 1 Aug 2005

Braat Henri, Stokkers Pieter, Hommes Tijmen, Cohn Danny, Vogels Esther, Pronk Inge, Spek Arnold, van Kampen Antoine, van Deventer Sander, Peppelenbosch Maikel, Hommes Daan

Abstract excerpt

The concept that mutations in germ-line encoded pattern recognition receptors with immune activating functions are associated with an increased incidence in Crohn's disease (CD) is gaining acceptance. Whether these mutations have similar or distinct effects on cellular physiology remains obscure. The incidence of three single nucleotide polymorphisms (SNPs) within the Nod2 gene and one functional SNP within both...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16010583
DOI: 10.1007/s00109-005-0685-x

Genes

NOD2
TLR4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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