Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nonobese diabetic (NOD) mice congenic for a targeted deletion of 12/15-lipoxygenase are protected from autoimmune diabetes.

Diabetes - 1 Jan 2008

McDuffie Marcia, Maybee Nelly A, Keller Susanna R, Stevens Brian K, Garmey James C, Morris Margaret A, Kropf Elizabeth, Rival Claudia, Ma Kaiwen, Carter Jeffrey D, Tersey Sarah A, Nunemaker Craig S, Nadler Jerry L

Abstract excerpt

OBJECTIVE: 12/15-lipoxygenase (12/15-LO), one of a family of fatty acid oxidoreductase enzymes, reacts with polyenoic fatty acids to produce proinflammatory lipids. 12/15-LO is expressed in macrophages and pancreatic beta-cells. It enhances interleukin 12 production by macrophages, and several of its products induce apoptosis of beta-cells at nanomolar concentrations in vitro. We had previously demonstrated a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arachidonate 12-Lipoxygenase
Share to Arachidonate 15-Lipoxygenase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 1

Share to Genome

Share to Macrophage Activation

Share to Mice, Inbred NOD

Source

Open in PubMed Open full text

Identifiers

PMID: 17940120
DOI: 10.2337/db07-0830
PMCID: PMC2993320

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nonobese diabetic (NOD) mice congenic for a targeted deletion of 12/15-lipoxygenase are protected from autoimmune diabetes.PMID 17940120Read ↗

A defective Il15 allele underlies the deficiency in natural killer cell activity in nonobese diabetic mice.Semantic proximity Read ↗

Molecular phenotyping of immune cells from young NOD mice reveals abnormal metabolic pathways in the early induction phase of autoimmune diabetes.Semantic proximity Read ↗

12-Lipoxygenase inhibition delays onset of autoimmune diabetes in human gene replacement miceSemantic proximity Read ↗

NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans.Semantic proximity Read ↗

12-Lipoxygenase inhibition improves glucose homeostasis and obesity-associated inflammation in human gene replacement miceSemantic proximity Read ↗

Macrophage 12/15 lipoxygenase expression increases plasma and hepatic lipid levels and exacerbates atherosclerosis.Semantic proximity Read ↗

Inhibition of Fas ligand in NOD mice unmasks a protective role for IL-10 against insulitis development.Semantic proximity Read ↗

15-Lipoxygenase promotes resolution of inflammation in lymphedema by controlling Treg cell function through IFN-βSemantic proximity Read ↗

15-Lipoxygenase drives inflammation resolution in lymphedema by controlling PPARg+Treg cell population traffickingSemantic proximity Read ↗

Nonobese diabetic mouse congenic analysis reveals chromosome 11 locus contributing to diabetes susceptibility, macrophage STAT5 dysfunction, and granulocyte-macrophage colony-stimulating factor overproduction.Semantic proximity Read ↗

Increased production of 12/15 lipoxygenase eicosanoids accelerates monocyte/endothelial interactions in diabetic db/db mice.Semantic proximity Read ↗

NOD mice contain an elevated frequency of iNKT17 cells that exacerbate diabetes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.