Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

15-Lipoxygenase promotes resolution of inflammation in lymphedema by controlling Treg cell function through IFN-β

4 Jan 2024

Abstract excerpt

Abstract Lymphedema (LD) is characterized by the accumulation of interstitial fluid, lipids and inflammatory cell infiltrate in the limb. Here, we find that LD tissues from women who developed LD after breast cancer exhibit an inflamed gene expression profile. Lipidomic analysis reveals decrease in specialized pro-resolving mediators (SPM) generated by the 15-lipoxygenase (15-LO) in LD. In mice, the loss of SPM...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Lymphatic System and Diseases
Share to Psoriasis: Treatment and Pathogenesis

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 38177096
DOI: 10.1038/s41467-023-43554-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

15-Lipoxygenase promotes resolution of inflammation in lymphedema by controlling Treg cell function through IFN-βPMID 38177096Read ↗

15-Lipoxygenase drives inflammation resolution in lymphedema by controlling PPARg+Treg cell population traffickingSemantic proximity Read ↗

12/15-Lipoxygenase orchestrates murine wound healing via PPARγ-activating oxylipins acting holistically to dampen inflammationSemantic proximity Read ↗

12-Lipoxygenase inhibition delays onset of autoimmune diabetes in human gene replacement miceSemantic proximity Read ↗

Lymphangiogenesis in Abdominal Aortic Aneurysm regulates the balance between resident and circulating eosinophils via a 15-lipoxygenase-dependent mechanismSemantic proximity Read ↗

Lymphangiogenesis in Abdominal Aortic Aneurysm regulates the balance between resident and circulating eosinophils via a 15-lipoxygenase-dependent mechanismSemantic proximity Read ↗

15-Lipoxygenase and its metabolites in the pathogenesis of breast cancer: A double-edged swordSemantic proximity Read ↗

12-Lipoxygenase inhibition improves glucose homeostasis and obesity-associated inflammation in human gene replacement miceSemantic proximity Read ↗

The lymphatics and the inflammatory response: lessons learned from human lymphedema.Semantic proximity Read ↗

The 12/15-lipoxygenase pathway counteracts fibroblast activation and experimental fibrosis.Semantic proximity Read ↗

Histopathologic Features of Lymphedema: A Molecular Review.Semantic proximity Read ↗

Key Regulatory Elements of the TGFβ-LRRC15 Axis Predict Disease Progression and Immunotherapy Resistance Across Cancer TypesSemantic proximity Read ↗

Regulation of inflammation and fibrosis by macrophages in lymphedema.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.