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Article

Macrophage 12/15 lipoxygenase expression increases plasma and hepatic lipid levels and exacerbates atherosclerosis.

Journal of lipid research - 1 Apr 2012

Rong Shunxing, Cao Qiang, Liu Mingxia, Seo Jeongmin, Jia Lin, Boudyguina Elena, Gebre Abraham K, Colvin Perry L, Smith Thomas L, Murphy Robert C, Mishra Nilamadhab, Parks John S

Abstract excerpt

12/15 lipoxygenase (12/15LO) oxidizes polyunsaturated fatty acids (PUFAs) to form bioactive lipid mediators. The role of 12/15LO in atherosclerosis development remains controversial. We evaluated atherosclerosis development and lipid metabolism in 12/15LO-LDL receptor (LDLr) double knockout (DK) vs. LDLr knockout (SK) mice fed a PUFA-enriched diet to enhance production of 12/15LO products. Compared with SK...

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Share to Arachidonate 12-Lipoxygenase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Diet, Atherogenic

Share to Fatty Acids, Unsaturated

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Identifiers

PMID: 22279185
DOI: 10.1194/jlr.M022723
PMCID: PMC3307645

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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