Article

12-Lipoxygenase inhibition improves glucose homeostasis and obesity-associated inflammation in human gene replacement mice

2025-01-13

Abstract excerpt

<h4>ABSTRACT</h4> Obesity-associated inflammation is characterized by macrophage infiltration into peripheral tissues, contributing to the progression of prediabetes and type 2 diabetes (T2D). The enzyme 12-lipoxygenase (12-LOX) catalyzes the formation of pro-inflammatory eicosanoids and is known to promote the migration of macrophages, yet its role in obesity-associated inflammation remains incompletely understo...

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Literature Corpus work: 21e10bfa-7e80-5137-88e4-5733f1f39613
DOI: 10.1101/2025.01.10.632274

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