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Article

Inhibition of Fas ligand in NOD mice unmasks a protective role for IL-10 against insulitis development.

The American journal of pathology - 1 Aug 2011

Xiao Zuoxiang, Mohamood Abdiaziz S, Uddin Sophia, Gutfreund Rachel, Nakata Chiaki, Marshall Andrew, Kimura Hiroaki, Caturegli Patrizio, Womer Karl L, Huang Yanfei, Jie Chunfa, Chakravarti Shukti, Schneck Jonathan P, Yagita Hideo, Hamad Abdel Rahim A

Abstract excerpt

Type 1 diabetes mellitus (T1D) is an autoimmune disease caused by the destruction of pancreatic insulin-producing β cells by autoreactive T cells early in life. Despite daily insulin injections, patients typically develop cardiovascular and other complications; and intensive efforts are being directed toward identifying therapeutic targets to prevent the disease without directly impinging on the host defense. Fas...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 21718680
DOI: 10.1016/j.ajpath.2011.04.016
PMCID: PMC3157218

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Inhibition of Fas ligand in NOD mice unmasks a protective role for IL-10 against insulitis development.PMID 21718680Read ↗

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