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Article

Molecular phenotyping of immune cells from young NOD mice reveals abnormal metabolic pathways in the early induction phase of autoimmune diabetes.

PloS one - 1 Jan 2012

Wu Jian, Kakoola Dorothy N, Lenchik Nataliya I, Desiderio Dominic M, Marshall Dana R, Gerling Ivan C

Abstract excerpt

Islet leukocytic infiltration (insulitis) is first obvious at around 4 weeks of age in the NOD mouse--a model for human type 1 diabetes (T1D). The molecular events that lead to insulitis and initiate autoimmune diabetes are poorly understood. Since TID is caused by numerous genes, we hypothesized that multiple molecular pathways are altered and interact to initiate this disease. We evaluated the molecular...

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Share to Diabetes Mellitus, Type 1
Share to Electrophoresis, Gel, Two-Dimensional

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukocytes

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Share to Mice, Inbred NOD

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Source

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Identifiers

PMID: 23071669
DOI: 10.1371/journal.pone.0046941
PMCID: PMC3469658

Genes

IFNG
MYC
MYCN
PRKCA
TGFB1
TNF
YWHAZ

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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