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Article

A defective Il15 allele underlies the deficiency in natural killer cell activity in nonobese diabetic mice.

Proceedings of the National Academy of Sciences of the United States of America - 18 May 2010

Suwanai Hirotsugu, Wilcox Martha Angela, Mathis Diane, Benoist Christophe

Abstract excerpt

The nonobese diabetic (NOD) mouse strain has a genetic deficiency in natural killer (NK) cells. This defect underlies this strain's utility in several experimental settings; in particular, it promotes engraftment of human tissue in NOD hosts during the generation of "humanized" mouse models. We h...

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Identifiers

PMID: 20439722
DOI: 10.1073/pnas.1004492107
PMCID: PMC2889097

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20439722-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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