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Article

Sequence Determinants for Amyloid Fibrillogenesis of Human alpha-Synuclein.

Journal of molecular biology - 23 Nov 2007

Zibaee Shahin, Jakes Ross, Fraser Graham, Serpell Louise C, Crowther R Anthony, Goedert Michel

Abstract excerpt

Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are characterized by the presence of filamentous inclusions in nerve cells. These filaments are amyloid fibrils that are made of the protein alpha-synuclein, which is genetically linked to rare cases of PD and DLB. beta-Synuclein, which shares 60% identity with alpha-synuclein, is not found in the inclusions. Furthermore, while recombinant...

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Identifiers

PMID: 17936783
DOI: 10.1016/j.jmb.2007.09.039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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