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Article

Molecular and Biological Compatibility with Host Alpha-Synuclein Influences Fibril Pathogenicity

1 Sept 2016

Abstract excerpt

The accumulation and propagation of misfolded α-synuclein (α-Syn) is a central feature of Parkinson's disease and other synucleinopathies. Molecular compatibility between a fibrillar seed and its native protein state is a major determinant of amyloid self-replication. We show that cross-seeded aggregation of human (Hu) and mouse (Ms) α-Syn is bidirectionally restricted. Although fibrils formed by Hu-Ms-α-Syn...

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PMID: 27653697
DOI: 10.1016/j.celrep.2016.08.053

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