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Article

Cryo-EM structure of alpha-synuclein fibrils.

eLife - 3 Jul 2018

Guerrero-Ferreira Ricardo, Taylor Nicholas Mi, Mona Daniel, Ringler Philippe, Lauer Matthias E, Riek Roland, Britschgi Markus, Stahlberg Henning

Abstract excerpt

Parkinson's disease is a progressive neuropathological disorder that belongs to the class of synucleinopathies, in which the protein alpha-synuclein is found at abnormally high concentrations in affected neurons. Its hallmark are intracellular inclusions called Lewy bodies and Lewy neurites. We here report the structure of cytotoxic alpha-synuclein fibrils (residues 1-121), determined by cryo-electron microscopy...

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Identifiers

PMID: 29969391
DOI: 10.7554/eLife.36402
PMCID: PMC6092118

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