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Article

Residue Glu83 plays a major role in negatively regulating alpha-synuclein amyloid formation.

Biochemical and biophysical research communications - 15 Jan 2010

Waxman Elisa A, Emmer Kristel L, Giasson Benoit I

Abstract excerpt

Alpha-synuclein (alpha-syn) amyloid filaments are the major ultrastructural component of pathological inclusions that define several neurodegenerative disorders, including Parkinson disease and other disorders that are collectively termed synucleinopathies. Since the aggregation of alpha-syn is associated with the etiology of these diseases, defining the molecular elements that influence this process may have...

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PMID: 20026050
DOI: 10.1016/j.bbrc.2009.12.079
PMCID: PMC2812690

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