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Article

The Pathological G51D Mutation in Alpha-Synuclein Oligomers Confers Distinct Structural Attributes and Cellular Toxicity.

Molecules (Basel, Switzerland) - 15 Feb 2022

Xu Catherine K, Castellana-Cruz Marta, Chen Serene W, Du Zhen, Meisl Georg, Levin Aviad, Mannini Benedetta, Itzhaki Laura S, Knowles Tuomas P J, Dobson Christopher M, Cremades Nunilo, Kumita Janet R

Abstract excerpt

A wide variety of oligomeric structures are formed during the aggregation of proteins associated with neurodegenerative diseases. Such soluble oligomers are believed to be key toxic species in the related disorders; therefore, identification of the structural determinants of toxicity is of upmost importance. Here, we analysed toxic oligomers of α-synuclein and its pathological variants in order to identify...

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Identifiers

PMID: 35209093
DOI: 10.3390/molecules27041293
PMCID: PMC8879557

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