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Article

Formation of toxic oligomeric alpha-synuclein species in living cells.

PloS one - 2 Apr 2008

Outeiro Tiago Fleming, Putcha Preeti, Tetzlaff Julie E, Spoelgen Robert, Koker Mirjam, Carvalho Filipe, Hyman Bradley T, McLean Pamela J

Abstract excerpt

BACKGROUND: Misfolding, oligomerization, and fibrillization of alpha-synuclein are thought to be central events in the onset and progression of Parkinson's disease (PD) and related disorders. Although fibrillar alpha-synuclein is a major component of Lewy bodies (LBs), recent data implicate prefibrillar, oligomeric intermediates as the toxic species. However, to date, oligomeric species have not been identified...

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Identifiers

PMID: 18382657
DOI: 10.1371/journal.pone.0001867
PMCID: PMC2270899

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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