Polymorphisms in nucleotide excision repair genes, polycyclic aromatic hydrocarbon-DNA adducts, and breast cancer risk.

doi:10.1158/1055-9965.EPI-07-0096

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Article

Polymorphisms in nucleotide excision repair genes, polycyclic aromatic hydrocarbon-DNA adducts, and breast cancer risk.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Oct 2007

Crew Katherine D, Gammon Marilie D, Terry Mary Beth, Zhang Fang Fang, Zablotska Lydia B, Agrawal Meenakshi, Shen Jing, Long Chang-Min, Eng Sybil M, Sagiv Sharon K, Teitelbaum Susan L, Neugut Alfred I, Santella Regina M

Abstract excerpt

Genes involved in the nucleotide excision repair (NER) pathway, which removes bulky DNA adducts, are potential low-penetrance cancer susceptibility genes. We recently reported an association between detectable polycyclic aromatic hydrocarbon (PAH)-DNA adducts and breast cancer risk. Using a population-based breast cancer case-control study on Long Island, New York, we examined whether polymorphisms in NER genes...

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PMID: 17932351
DOI: 10.1158/1055-9965.EPI-07-0096

Genes

PAH
ERCC1
XPA

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