DNA adducts, DNA repair genotype/phenotype and cancer risk.

doi:10.1016/j.mrfmmm.2005.06.001

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Article

DNA adducts, DNA repair genotype/phenotype and cancer risk.

Mutation research - 30 Dec 2005

Santella Regina M, Gammon Marilie, Terry MaryBeth, Senie Ruby, Shen Jing, Kennedy David, Agrawal Meenakshi, Faraglia Beatrice, Zhang FangFang

Abstract excerpt

It is well established that the initiating event in chemical carcinogenesis is the binding of reactive carcinogens to DNA. Thus, a number of analytic methods have been developed for determining levels of carcinogen-DNA adducts in humans as a marker of individual exposure and, potentially, of risk for cancer development. We have developed monoclonal and polyclonal antibodies to carcinogen-DNA adducts and highly...

Topics

Breast Neoplasms
Carcinogens
DNA Adducts
DNA Repair
Female
Genotype
Humans
Neoplasms
Phenotype
Risk Assessment
Smoking

Source

Open in PubMed

Identifiers

PMID: 16023682
DOI: 10.1016/j.mrfmmm.2005.06.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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