Article
Polymorphisms in XRCC1 modify the association between polycyclic aromatic hydrocarbon-DNA adducts, cigarette smoking, dietary antioxidants, and breast cancer risk.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Feb 2005
Shen Jing, Gammon Marilie D, Terry Mary Beth, Wang Lianwen, Wang Qiao, Zhang Fangfang, Teitelbaum Susan L, Eng Sybil M, Sagiv Sharon K, Gaudet Mia M, Neugut Alfred I, Santella Regina M
Abstract excerpt
The variability in DNA repair capacity of the general population may depend in part upon common variants in DNA repair genes. X-ray repair cross complementing group 1 (XRCC1) is an important DNA base excision repair gene and exhibits polymorphic variation. Using the Long Island Breast Cancer Study Project, a population-based case-control study, we evaluated the hypothesis that two common single nucleotide...
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