Article
Polymorphisms in the DNA repair enzyme XPD are associated with increased levels of PAH-DNA adducts in a case-control study of breast cancer.
Breast cancer research and treatment - 1 Sept 2002
Tang Deliang, Cho Stan, Rundle Andrew, Chen Senqing, Phillips David, Zhou Jingzhi, Hsu Yanzhi, Schnabel Freya, Estabrook Alison, Perera Frederica P
Abstract excerpt
We present findings on the associations between DNA adduct levels in breast tissue, risk of breast cancer, and polymorphisms in the DNA repair enzyme XPD. Breast cancer cases, benign breast disease (BBD) controls, and healthy controls were enrolled. Polycyclic aromatic hydrocarbons (PAH)-DNA adduct levels were measured by immunohistochemistry in breast tissue samples from cases and BBD controls. XPD polymorphisms...
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