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Article

The stability and aggregation of ovine prion protein associated with classical and atypical scrapie correlates with the ease of unwinding of helix-2.

The Biochemical journal - 15 Jan 2008

Fitzmaurice Tim J, Burke David F, Hopkins Lee, Yang Sujeong, Yu Shuiliang, Sy Man-Sun, Thackray Alana M, Bujdoso Raymond

Abstract excerpt

Susceptibility to scrapie disease in sheep, the archetypal prion disease, correlates with polymorphisms within the ovine PrP (prion-related protein) gene. The VRQ (Val136Arg154Gln171) and AL141RQ (Ala136Leu141Arg154Gln171) allelic variants are associated with classical scrapie, whereas the ARR (Ala136Arg154Arg171), AF141RQ (Ala136Phe141Arg154Gln171) and AHQ (Ala136His154Gln171) allelic variants are associated...

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Identifiers

PMID: 17931166
DOI: 10.1042/BJ20071122

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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