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Article

Influence of the prion protein gene, Prnp, on scrapie susceptibility in sheep.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica - 1 Jan 2002

Tranulis Michael A

Abstract excerpt

Natural scrapie in sheep occurs through a complex interplay between host genetic elements and various strains of the infectious scrapie agent. Scrapie-related polymorphisms in the coding region of the prion protein (PrP) gene, Prnp, have been studied in a number of breeds. The disease-promoting V136 allele, and the susceptibility-reducing R171 allele, have proved to be most important. However, variation in the...

Topics

Alleles
Amyloid
Animals
Genetic Markers
Genetic Predisposition to Disease
Prions
Protein Precursors
Scrapie
Sheep

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 12064254
DOI: 10.1034/j.1600-0463.2002.100105.x

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