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Article

Nanopore analysis reveals differences in structural stability of ovine PrP(C) proteins corresponding to scrapie susceptible (VRQ) and resistance (ARR) genotypes.

Prion - 1 Jan 2000

Madampage Claudia Avis, Marciniuk Kristen, Määttänen Pekka, Cashman Neil R, Potter Andrew, Lee Jeremy S, Napper Scott

Abstract excerpt

Species, as well as individuals within species, have unique susceptibilities to prion infection that are likely based on sequence differences in cellular prion protein (PrP(C)). Species barriers to transmission also reflect PrP(C) sequence differences. Defining the structure-activity relationship of PrP(C)/PrP(Sc) with respect to infectivity/susceptibility will benefit disease understanding and assessment of...

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Identifiers

PMID: 24401607
DOI: 10.4161/pri.27502
PMCID: PMC4201620

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