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Article

Novel Variations in Native Ethiopian Goat breeds PRNP Gene and Their Potential Effect on Prion Protein Stability.

Scientific reports - 24 Apr 2020

Teferedegn Eden Yitna, Yaman Yalçın, Ün Cemal

Abstract excerpt

Scrapie is a lethal neurodegenerative disease of sheep and goats caused by the misfolding of the prion protein. Variants such as M142, D145, S146, H154, Q211, and K222 were experimentally found to increase resistance or extend scrapie incubation period in goats. We aimed to identify polymorphisms in the Afar and Arsi-Bale goat breeds of Ethiopia and computationally assess the effect of variants on prion protein...

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Identifiers

PMID: 32332800
DOI: 10.1038/s41598-020-63874-z
PMCID: PMC7181617

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