Article
The PrP(C) C1 fragment derived from the ovine A136R154R171PRNP allele is highly abundant in sheep brain and inhibits fibrillisation of full-length PrP(C) protein in vitro.
Biochimica et biophysica acta - 1 Jun 2013
Campbell Lauren, Gill Andrew C, McGovern Gillian, Jalland Clara M O, Hopkins John, Tranulis Michael A, Hunter Nora, Goldmann Wilfred
Abstract excerpt
Expression of the cellular prion protein (PrP(C)) is crucial for the development of prion diseases. Resistance to prion diseases can result from reduced availability of the prion protein or from amino acid changes in the prion protein sequence. We propose here that increased production of a natural PrP α-cleavage fragment, C1, is also associated with resistance to disease. We show, in brain tissue, that ARR...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.