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Article

Amyloidogenic unfolding intermediates differentiate sheep prion protein variants.

Journal of molecular biology - 27 Sept 2002

Rezaei Human, Choiset Yvan, Eghiaian Frederic, Treguer Eric, Mentre Pascale, Debey Pascale, Grosclaude Jeanne, Haertle Thomas

Abstract excerpt

Sheep is a unique example among mammalian species to present a strong correlation between genotype and prion disease susceptibility phenotype. Indeed a well-defined set of PrP polymorphisms at positions 136, 154 and 171 (sheep numbering) govern scrapie susceptibility, ranging from very high susceptibility for V136-R154-Q171 variant (VRQ) to resistance for A136-R154-R171 variant (ARR). To get better insight into...

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Identifiers

PMID: 12270715
DOI: 10.1016/s0022-2836(02)00856-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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