Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphisms at amino acid residues 141 and 154 influence conformational variation in ovine PrP.

BioMed research international - 1 Jan 2014

Yang Sujeong, Thackray Alana M, Hopkins Lee, Monie Tom P, Burke David F, Bujdoso Raymond

Abstract excerpt

Polymorphisms in ovine PrP at amino acid residues 141 and 154 are associated with susceptibility to ovine prion disease: Leu141Arg154 with classical scrapie and Phe141Arg154 and Leu141His154 with atypical scrapie. Classical scrapie is naturally transmissible between sheep, whereas this may not be the case with atypical scrapie. Critical amino acid residues will determine the range or stability of structural...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Amino Acids
Share to Molecular Dynamics Simulation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Prions

Share to Protein Conformation

Share to Protein Structure, Secondary

Share to Scrapie

Source

Open in PubMed Open full text

Identifiers

PMID: 25126555
DOI: 10.1155/2014/372491
PMCID: PMC4122135

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphisms at amino acid residues 141 and 154 influence conformational variation in ovine PrP.PMID 25126555Read ↗

The stability and aggregation of ovine prion protein associated with classical and atypical scrapie correlates with the ease of unwinding of helix-2.Semantic proximity Read ↗

Polymorphisms at codons 141 and 154 in the ovine prion protein gene are associated with scrapie Nor98 cases.Semantic proximity Read ↗

Simultaneous detection of eight single nucleotide polymorphisms in the ovine prion protein gene.Semantic proximity Read ↗

Novel Variations in Native Ethiopian Goat breeds PRNP Gene and Their Potential Effect on Prion Protein Stability.Semantic proximity Read ↗

Structural differences between allelic variants of the ovine prion protein revealed by molecular dynamics simulations.Semantic proximity Read ↗

Polymorphism of prion protein gene (PRNP) in Nigerian sheep.Semantic proximity Read ↗

Scrapie-associated polymorphisms of the prion protein gene (PRNP) in Nigerian native goats.Semantic proximity Read ↗

Amyloidogenic unfolding intermediates differentiate sheep prion protein variants.Semantic proximity Read ↗

Prion protein gene (PRNP) polymorphisms in Xinjiang local sheep breeds in China.Semantic proximity Read ↗

Large-scale survey of prion protein genetic variability in scrapie disease-free goats from the United States.Semantic proximity Read ↗

Allelic variants of ovine prion protein gene (PRNP) in Oklahoma sheep.Semantic proximity Read ↗

Caprine PRNP polymorphisms N146S and Q222K are associated with proteolytic cleavage of PrPC.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.