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Article

Determining the Relative Susceptibility of Four Prion Protein Genotypes to Atypical Scrapie.

Analytical chemistry - 16 Jan 2018

Silva Christopher J, Erickson-Beltran Melissa L, Martín-Burriel Inmaculada, Badiola Juan José, Requena Jesús R, Bolea Rosa

Abstract excerpt

Atypical scrapie is a sheep prion (PrPSc) disease whose epidemiology is consistent with a sporadic origin and is associated with specific polymorphisms of the normal cellular prion protein (PrPC). To determine the relative amounts of PrP polymorphisms present in atypical scrapie, total PrP was digested with chymotrypsin to generate characteristic peptides spanning relevant polymorphisms at positions 136, 141,...

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Identifiers

PMID: 29240410
DOI: 10.1021/acs.analchem.7b03985

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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