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Article

Copper induces increased beta-sheet content in the scrapie-susceptible ovine prion protein PrPVRQ compared with the resistant allelic variant PrPARR.

The Biochemical journal - 15 May 2004

Wong Edmond, Thackray Alana M, Bujdoso Raymond

Abstract excerpt

Prion diseases are characterized by conformational change in the copper-binding protein PrP (prion protein). Polymorphisms in ovine PrP at amino acid residues 136, 154 and 171 are associated with variation in susceptibility to scrapie. PrPVRQ [PrP(Val136/Arg154/Gln171)] or PrPARQ [PrP(Ala136/Arg154/Gln171)] animals show susceptibility to scrapie, whereas those that express Ala136/Arg154/Arg171 (PrPARR) show...

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Identifiers

PMID: 14969585
DOI: 10.1042/BJ20031767
PMCID: PMC1224157

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