Article
An alternate mechanism of abortive release marked by the formation of very long abortive transcripts.
Biochemistry - 6 Nov 2007
Chander Monica, Austin Karyn M, Aye-Han Nwe-Nwe, Sircar Piya, Hsu Lilian M
Abstract excerpt
The Esigma70-dependent N25 promoter is rate-limited at promoter escape. Here, RNA polymerase repeatedly initiates and aborts transcription, giving rise to a ladder of short RNAs 2-11 nucleotides long. Certain mutations in the initial transcribed sequence (ITS) of N25 lengthen the abortive initiation program, resulting in the release of very long abortive transcripts (VLATs) 16-19 nucleotides long. This phenomenon...
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