Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Early embryonic lethality caused by targeted disruption of the TRAF-interacting protein (TRIP) gene.

Biochemical and biophysical research communications - 30 Nov 2007

Park Eui-Soon, Choi Seunga, Kim Jin-Man, Jeong Yongsu, Choe Joonho, Park Chang-Sik, Choi Yongwon, Rho Jaerang

Abstract excerpt

Tumor necrosis factor receptor (TNFR)-associated factors (TRAFs) are key adaptor molecules in the TNFR-signaling complexes that promote a wide variety of signaling cascades including cell proliferation, activation, differentiation, and apoptosis. TRAF-interacting protein (TRIP) is required for the inhibitory regulation of TNF-induced NF-kappaB signaling via the TNFR/TRAF-signaling complexes in vitro. TRIP also...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Proliferation
Share to Down-Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryo Loss

Share to Gene Deletion

Share to NIH 3T3 Cells

Share to RNA, Small Interfering

Share to Tumor Necrosis Factor-alpha

Share to Tumor Necrosis Factor Receptor-Associated Peptides and Proteins

Source

Identifiers

PMID: 17927961
DOI: 10.1016/j.bbrc.2007.09.103

Genes

CYLD
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Early embryonic lethality caused by targeted disruption of the TRAF-interacting protein (TRIP) gene.PMID 17927961Read ↗

The Tumor Suppressor CYLD Interacts with TRIP and Regulates Negatively Nuclear Factor κB Activation by Tumor Necrosis FactorSemantic proximity Read ↗

The Emerging Role of TRAF7 in Tumor Development.Semantic proximity Read ↗

Genetic Alterations of TRAF Proteins in Human CancersSemantic proximity Read ↗

Identification and characterization of Xenopus laevis homologs of mammalian TRAF6 and its binding protein TIFA.Semantic proximity Read ↗

Discrete functions of TRAF1 and TRAF2 in Drosophila melanogaster mediated by c-Jun N-terminal kinase and NF-kappaB-dependent signaling pathways.Semantic proximity Read ↗

TAK1 participates in c-Jun N-terminal kinase signaling during Drosophila development.Semantic proximity Read ↗

The RIPK1 death domain restrains ZBP1- and TRIF-mediated cell death and inflammation.Semantic proximity Read ↗

Tumor suppressor CYLD regulates JNK-induced cell death in Drosophila.Semantic proximity Read ↗

TRAF4 functions as an intermediate of GITR-induced NF-kappaB activation.Semantic proximity Read ↗

Analogies between Drosophila and mammalian TRAF pathways.Semantic proximity Read ↗

A candidate gene for the amnionless gastrulation stage mouse mutation encodes a TRAF-related protein.Semantic proximity Read ↗

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.