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Article

Identification and characterization of Xenopus laevis homologs of mammalian TRAF6 and its binding protein TIFA.

Gene - 26 Sept 2005

Inoue Jun-Ichiro, Yagi Shigenori, Ishikawa Kosuke, Azuma Sakura, Ikawa Shuntaro, Semba Kentaro

Abstract excerpt

Tumor necrosis factor receptor (TNFR)-associated factor 6 (TRAF6) transduces signals from members of the TNFR superfamily and the Toll/IL-1R family, leading to activation of transcription factors such as NFkappaB and AP-1. Genetic disruption of the TRAF6 gene in mice results in various developmental abnormalities during embryogenesis, including osteopetrosis, failure of neural tube closure, defective formation of...

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Source

Identifiers

PMID: 16023795
DOI: 10.1016/j.gene.2005.05.016

Genes

TRAF6
TIFA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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