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Article

Discrete functions of TRAF1 and TRAF2 in Drosophila melanogaster mediated by c-Jun N-terminal kinase and NF-kappaB-dependent signaling pathways.

Molecular and cellular biology - 1 Nov 2003

Cha Guang-Ho, Cho Kyoung Sang, Lee Jun Hee, Kim Myungjin, Kim Euysoo, Park Jeehye, Lee Sung Bae, Chung Jongkyeong

Abstract excerpt

Two Drosophila tumor necrosis factor receptor-associated factors (TRAF), DTRAF1 and DTRAF2, are proposed to have similar functions with their mammalian counterparts as a signal mediator of cell surface receptors. However, their in vivo functions and related signaling pathways are not fully understood yet. Here, we show that DTRAF1 is an in vivo regulator of c-Jun N-terminal kinase (JNK) pathway in Drosophila...

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Source

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Identifiers

PMID: 14585960
DOI: 10.1128/MCB.23.22.7982-7991.2003
PMCID: PMC262421

Genes

TRAF1
TRAF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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