Genetic Alterations of TRAF Proteins in Human Cancers

Abstract excerpt

The tumor necrosis factor receptor (TNF-R)-associated factor (TRAF) family of cytoplasmic adaptor proteins regulate the signal transduction pathways of a variety of receptors, including the TNF-R superfamily, Toll-like receptors (TLRs), NOD-like receptors (NLRs), RIG-I-like receptors (RLRs) and cytokine receptors. TRAF-dependent signaling pathways participate in a diverse array of important cellular processes,...

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