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Article

TRAF7 in signaling and disease: emerging mechanisms and clinical implications.

Molecular medicine (Cambridge, Mass.) - 11 Dec 2025

Orock Albert, Zuccato Jeffrey A, Phan Khanh, Liu Yufeng, Ihuoma Jennifer, Tavakol Sherwin, Tsytsykova Alla V, Tsitsikov Erdyni N, Tarantini Stefano, Johnson Anthony C, Dunn Ian F

Abstract excerpt

Tumor necrosis factor receptor-associated factors (TRAFs) are a family of 7 signaling proteins that have regulatory roles in multiple fundamental cellular processes, including immunity, inflammation, apoptosis, permeability, and cell proliferation. TRAF7 is the most recently described with unique features distinguishing it from other TRAFs. It is an E3 ubiquitin ligase that activates MEKK3 and KLF2/4 signaling,...

Read the complete abstract on PubMed

Topics

Humans
Signal Transduction
Tumor Necrosis Factor Receptor-Associated Peptides and Proteins
Animals
Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 41372821
DOI: 10.1186/s10020-025-01401-4
PMCID: PMC12801879

Genes

TRAF7
KLF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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