Capu and Spire assemble a cytoplasmic actin mesh that maintains microtubule organization in the Drosophila oocyte.

doi:10.1016/j.devcel.2007.09.003

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Article

Capu and Spire assemble a cytoplasmic actin mesh that maintains microtubule organization in the Drosophila oocyte.

Developmental cell - 1 Oct 2007

Dahlgaard Katja, Raposo Alexandre A S F, Niccoli Teresa, St Johnston Daniel

Abstract excerpt

Mutants in the actin nucleators Cappuccino and Spire disrupt the polarized microtubule network in the Drosophila oocyte that defines the anterior-posterior axis, suggesting that microtubule organization depends on actin. Here, we show that Cappuccino and Spire organize an isotropic mesh of actin filaments in the oocyte cytoplasm. capu and spire mutants lack this mesh, whereas overexpressed truncated Cappuccino...

Topics

Actins
Animals
Cytoplasm
Drosophila
Drosophila Proteins
Female
Kinesins
Microfilament Proteins
Microtubules
Mutation
Oocytes

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Identifiers

PMID: 17925229
DOI: 10.1016/j.devcel.2007.09.003
PMCID: PMC2034408

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