Article
The role of γ-tubulin in centrosomal microtubule organization.
PloS one - 1 Jan 2012
O'Toole Eileen, Greenan Garrett, Lange Karen I, Srayko Martin, Müller-Reichert Thomas
Abstract excerpt
As part of a multi-subunit ring complex, γ-tubulin has been shown to promote microtubule nucleation both in vitro and in vivo, and the structural properties of the complex suggest that it also seals the minus ends of the polymers with a conical cap. Cells depleted of γ-tubulin, however, still display many microtubules that participate in mitotic spindle assembly, suggesting that γ-tubulin is not absolutely...
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