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Article

Spire stimulates nucleation by Cappuccino and binds both ends of actin filaments.

Molecular biology of the cell - 15 Feb 2020

Bradley Alexander O, Vizcarra Christina L, Bailey Hannah M, Quinlan Margot E

Abstract excerpt

The actin nucleators Spire and Cappuccino synergize to promote actin assembly, but the mechanism of their synergy is controversial. Together these proteins promote the formation of actin meshes, which are conserved structures that regulate the establishment of oocyte polarity. Direct interaction between Spire and Cappuccino is required for oogenesis and for in vitro synergistic actin assembly. This synergy is...

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Identifiers

PMID: 31877067
DOI: 10.1091/mbc.E19-09-0550
PMCID: PMC7183766

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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