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Article

Aberrant cortex contractions impact mammalian oocyte quality

21 Feb 2024

Abstract excerpt

The cortex controls cell shape. In mouse oocytes, the cortex thickens in an Arp2/3-complex-dependent manner, ensuring chromosome positioning and segregation. Surprisingly, we identify that mouse oocytes lacking the Arp2/3 complex undergo cortical actin remodeling upon division, followed by cortical contractions that are unprecedented in mammalian oocytes. Using genetics, imaging, and machine learning, we show...

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Identifiers

PMID: 38387459
DOI: 10.1016/j.devcel.2024.01.027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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