Article
Drosophila Cappuccino alleles provide insight into formin mechanism and role in oogenesis.
Molecular biology of the cell - 15 May 2015
Yoo Haneul, Roth-Johnson Elizabeth A, Bor Batbileg, Quinlan Margot E
Abstract excerpt
During Drosophila development, the formin actin nucleator Cappuccino (Capu) helps build a cytoplasmic actin mesh throughout the oocyte. Loss of Capu leads to female sterility, presumably because polarity determinants fail to localize properly in the absence of the mesh. To gain deeper insight into how Capu builds this actin mesh, we systematically characterized seven capu alleles, which have missense mutations in...
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