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Article

A mitochondrial unfolded protein response-independent role of DVE-1 in longevity regulation.

Cell reports - 26 Nov 2024

Sheng Yi, Abreu Adriana, Markovich Zachary, Ebea Pearl, Davis Leah, Park Eric, Sheng Peike, Xie Mingyi, Han Sung Min, Xiao Rui

Abstract excerpt

The special AT-rich sequence-binding (SATB) protein DVE-1 is widely recognized for its pivotal involvement in orchestrating the retrograde mitochondrial unfolded protein response (mitoUPR) in C. elegans. In our study of downstream factors contributing to lifespan extension in sensory ciliary mutants, we find that DVE-1 is crucial for this longevity effect independent of its canonical mitoUPR function....

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Identifiers

PMID: 39423131
DOI: 10.1016/j.celrep.2024.114889
PMCID: PMC11648574

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