Article
The zebrafish ennui behavioral mutation disrupts acetylcholine receptor localization and motor axon stability.
Developmental neurobiology - 1 Jan 2008
Saint-Amant Louis, Sprague Shawn M, Hirata Hiromi, Li Qin, Cui Wilson W, Zhou Weibin, Poudou Olivier, Hume Richard I, Kuwada John Y
Abstract excerpt
The zebrafish ennui mutation was identified from a mutagenesis screen for defects in early behavior. Homozygous ennui embryos swam more slowly than wild-type siblings but normal swimming recovered during larval stages and homozygous mutants survived until adulthood. Electrophysiological recordings from motoneurons and muscles suggested that the motor output of the CNS following mechanosensory stimulation was...
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