The atypical cadherin flamingo regulates synaptogenesis and helps prevent axonal and synaptic degeneration in Drosophila.

doi:10.1016/j.mcn.2007.01.007

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Article

The atypical cadherin flamingo regulates synaptogenesis and helps prevent axonal and synaptic degeneration in Drosophila.

Molecular and cellular neurosciences - 1 Apr 2007

Bao Hong, Berlanga Monica L, Xue Mingshan, Hapip Sara M, Daniels Richard W, Mendenhall John M, Alcantara Adriana A, Zhang Bing

Abstract excerpt

The formation of synaptic connections with target cells and maintenance of axons are highly regulated and crucial for neuronal function. The atypical cadherin and G-protein-coupled receptor Flamingo and its orthologs in amphibians and mammals have been shown to regulate cell polarity, dendritic and axonal growth, and neural tube closure. However, the role of Flamingo in synapse formation and function and in...

Topics

Animals
Axons
Cadherins
Central Nervous System
Drosophila
Drosophila Proteins
Image Processing, Computer-Assisted
Immunohistochemistry
Microscopy, Confocal
Microscopy, Electron, Transmission

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Nerve Degeneration

Neuromuscular Junction

Organogenesis

Patch-Clamp Techniques

Synapses

Source

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Identifiers

PMID: 17321750
DOI: 10.1016/j.mcn.2007.01.007
PMCID: PMC1885973

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