Pathfinding and synapse formation in a zebrafish mutant lacking functional acetylcholine receptors.

doi:10.1016/0896-6273(90)90139-7

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Article

Pathfinding and synapse formation in a zebrafish mutant lacking functional acetylcholine receptors.

Neuron - 1 Jun 1990

Westerfield M, Liu D W, Kimmel C B, Walker C

Abstract excerpt

We induced and characterized a recessive lethal mutation, nic-1, in zebrafish that blocks the function of muscle acetylcholine (ACh) receptors. Homozygous nic-1 embryos are nonmotile and fail to respond to exogenous application of cholinergic agonists, although their muscles contract in response to direct electrical stimulation. Moreover, we do not detect cell surface labeling by alpha-bungarotoxin or monoclonal...

Topics

Animals
Antibodies, Monoclonal
Axons
Bungarotoxins
Cyprinidae
Electric Stimulation
Embryo, Nonmammalian
Genes, Lethal
Genes, Recessive
Macromolecular Substances
Membrane Potentials

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microscopy, Electron

Motor Neurons

Muscles

Mutation

Neuromuscular Junction

Receptors, Cholinergic

Synapses

Source

Open in PubMed

Identifiers

PMID: 2361010
DOI: 10.1016/0896-6273(90)90139-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2361010-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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