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Article

Pathfinding and synapse formation in a zebrafish mutant lacking functional acetylcholine receptors.

Neuron - 1 Jun 1990

Westerfield M, Liu D W, Kimmel C B, Walker C

Abstract excerpt

We induced and characterized a recessive lethal mutation, nic-1, in zebrafish that blocks the function of muscle acetylcholine (ACh) receptors. Homozygous nic-1 embryos are nonmotile and fail to respond to exogenous application of cholinergic agonists, although their muscles contract in response to direct electrical stimulation. Moreover, we do not detect cell surface labeling by alpha-bungarotoxin or monoclonal...

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PMID: 2361010
DOI: 10.1016/0896-6273(90)90139-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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