Agrin/Lrp4 signal constrains MuSK-dependent neuromuscular synapse development in appendicular muscle.

doi:10.1242/dev.199790

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Article

Agrin/Lrp4 signal constrains MuSK-dependent neuromuscular synapse development in appendicular muscle.

Development (Cambridge, England) - 1 Nov 2021

Walker Lauren J, Roque Rebecca A, Navarro Maria F, Granato Michael

Abstract excerpt

The receptor tyrosine kinase MuSK, its co-receptor Lrp4 and the Agrin ligand constitute a signaling pathway that is crucial in axial muscle for neuromuscular synapse development, yet whether this pathway functions similarly in appendicular muscle is unclear. Here, using the larval zebrafish pectoral fin, equivalent to tetrapod forelimbs, we show that, similar to axial muscle, developing appendicular muscles form...

Topics

Agrin
Animal Fins
Animals
Axons
Homeodomain Proteins
LDL-Receptor Related Proteins
Muscle, Skeletal
Mutation
Neuromuscular Junction
Receptors, Cholinergic
Signal Transduction
Zebrafish
Zebrafish Proteins

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Identifiers

PMID: 34714331
DOI: 10.1242/dev.199790
PMCID: PMC8602948

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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