Article
Drosophila Nesprin-1 controls glutamate receptor density at neuromuscular junctions.
Cellular and molecular life sciences : CMLS - 1 Sept 2014
Morel Véronique, Lepicard Simon, Rey Alexandre N, Parmentier Marie-Laure, Schaeffer Laurent
Abstract excerpt
Nesprin-1 is a core component of a protein complex connecting nuclei to cytoskeleton termed LINC (linker of nucleoskeleton and cytoskeleton). Nesprin-1 is anchored to the nuclear envelope by its C-terminal KASH domain, the disruption of which has been associated with neuronal and neuromuscular pathologies, including autosomal recessive cerebellar ataxia and Emery-Dreifuss muscular dystrophy. Here, we describe a...
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