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Article

Distinct roles of muscle and motoneuron LRP4 in neuromuscular junction formation.

Neuron - 12 Jul 2012

Wu Haitao, Lu Yisheng, Shen Chengyong, Patel Neil, Gan Lin, Xiong Wen C, Mei Lin

Abstract excerpt

Neuromuscular junction (NMJ) formation requires precise interaction between motoneurons and muscle fibers. LRP4 is a receptor of agrin that is thought to act in cis to stimulate MuSK in muscle fibers for postsynaptic differentiation. Here we dissected the roles of LRP4 in muscle fibers and motoneurons in NMJ formation by cell-specific mutation. Studies of muscle-specific mutants suggest that LRP4 is involved in...

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Source

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Identifiers

PMID: 22794264
DOI: 10.1016/j.neuron.2012.04.033
PMCID: PMC3422364

Genes

LRP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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