Article
Autonomous expression of the nic1 acetylcholine receptor mutation in zebrafish muscle cells.
Developmental biology - 1 Jan 1994
Sepich D S, Ho R K, Westerfield M
Abstract excerpt
The nic1b107 (nic1) mutation blocks expression of both functional and clustered acetylcholine receptors (AChRs) in zebrafish muscle. Normally, signaling between motoneurons and muscles regulates AChR clustering. To learn if signaling is affected and to identify the primary cellular target of the nic1 mutation, we made mosaic embryos by transplanting motoneurons and muscle precursors from wild-type to mutant...
Topics
- Animals
- Cell Differentiation
- Cells, Cultured
- Female
- Motor Neurons
- Muscles
- Mutation
- Receptors, Cholinergic
- Zebrafish